Tweet
Dans la pharmacopée ancienne, l'Oubaine etait utilisée contre les problemes du coeur dont les arrythmies cardiaques.
Apres l'influence du charlatan Rockefeller sur l'industrie pharmaceutique et l'education medicale aux Etudes-Unis, l'Oubaine etait considérée comme une huile de serpent ( Snake oil).
Mais d'apres les recherches recentes, cette molecule extraite de plante est le plus puissant medicament cardiaque.
l'Oubaine arrete la progression de l'artherosclerose en aidant le coeur a se debarasser de l'acide lactique par l'ouverture des capillaires sanguins du vasa vasurum.
l'Aubaine est aussi une molecule endogene secretée par la glande surrenale.
Apres l'influence du charlatan Rockefeller sur l'industrie pharmaceutique et l'education medicale aux Etudes-Unis, l'Oubaine etait considérée comme une huile de serpent ( Snake oil).
Mais d'apres les recherches recentes, cette molecule extraite de plante est le plus puissant medicament cardiaque.
l'Oubaine arrete la progression de l'artherosclerose en aidant le coeur a se debarasser de l'acide lactique par l'ouverture des capillaires sanguins du vasa vasurum.
l'Aubaine est aussi une molecule endogene secretée par la glande surrenale.
Endogenous ouabain in cardiovascular function and disease.
Manunta P1, Ferrandi M, Bianchi G, Hamlyn JM.
Author information
1
San Raffaele Scientific Institute, Division of Nephrology, Dialysis, and Hypertension, Universita' Vita-Salute San Raffaele Hospital, Milan, Italy. [email protected]
Abstract
An endogenous ouabain has been isolated and conclusively identified from several mammalian tissues, including human plasma, by a number of independent laboratories. Substantial evidence from independent laboratories in several continents is consistent with an adrenal source for most if not all of the circulating endogenous ouabain. Accumulating evidence suggests that circulating levels of endogenous ouabain in humans are modulated by dietary salt and chronic volume status. Endogenous ouabain is linked significantly with vascular function in hypertension and likely impacts the pathogenesis of heart and renal failure. Moreover, the molecular mechanism of endogenous ouabain-linked hypertension involves the sodium pump/sodium-calcium exchange duet. The outstanding analytical issues include the elucidation of distal events in the biosynthetic pathway for endogenous ouabain and identification of molecular mechanisms that regulate its secretion and clearance.
Manunta P1, Ferrandi M, Bianchi G, Hamlyn JM.
Author information
1
San Raffaele Scientific Institute, Division of Nephrology, Dialysis, and Hypertension, Universita' Vita-Salute San Raffaele Hospital, Milan, Italy. [email protected]
Abstract
An endogenous ouabain has been isolated and conclusively identified from several mammalian tissues, including human plasma, by a number of independent laboratories. Substantial evidence from independent laboratories in several continents is consistent with an adrenal source for most if not all of the circulating endogenous ouabain. Accumulating evidence suggests that circulating levels of endogenous ouabain in humans are modulated by dietary salt and chronic volume status. Endogenous ouabain is linked significantly with vascular function in hypertension and likely impacts the pathogenesis of heart and renal failure. Moreover, the molecular mechanism of endogenous ouabain-linked hypertension involves the sodium pump/sodium-calcium exchange duet. The outstanding analytical issues include the elucidation of distal events in the biosynthetic pathway for endogenous ouabain and identification of molecular mechanisms that regulate its secretion and clearance.